PHILOSOPHY
We will contribute to our society and global health by research, development and commercialization of innovative medicines for patients suffering from incurable diseases.
OUR BUSINESS
Research and development of HGF protein medicines
Kringle Pharma, a late clinical-stage biopharmaceutical company developing recombinant human hepatocyte growth factor for incurable diseases such as acute spinal cord injury and ALS, announces the closing of its initial public offering on the Tokyo Stock Exchange Mothers market.
Kringle Pharma and Maruishi Pharmaceutical enter into a capital and business partnership for KP-100IT in acute spinal cord injury.
PDFKringle initiates Phase 3 clinical trial of recombinant human HGF for the treatment of acute spinal cord injury.
PDFKringle Pharma announces that positive clinical results from Phase I/II trial of recombinant human HGF, KP-100IT, in subjects with acute spinal cord injury were published in the peer-reviewed Journal of Neurotrauma (Published Online: 22 May 2020, DOI: 10.1089/neu.2019.6854).
Kringle Pharma additionally raises 740 million Japanese yen toward commercialization of recombinant human HGF drug.
PDFKringle Pharma successfully raises 950 million Japanese yen to advance clinical development of recombinant human HGF.
PDFKringle Pharma and Toho Holdings enter into a capital and business alliance for KP-100IT in acute spinal cord injury.
PDFNew board members were selected at the 18th general shareholders meeting, and the board members appointed Kiichi Adachi as President and CEO.
KP-100IT, recombinant human HGF for the treatment of acute spinal cord injury, was designated as an orphan drug in Japan as of September 12, 2019, with the approval of the Minister of Health, Labor and Welfare.
Phase I/II study of recombinant human HGF, KP-100IT, for acute spinal cord injury was completed, and the clinical study report has been issued. The positive results of this study will be published later in a scientific journal and presented at academic conferences.
Clinical data from Phase I study of recombinant human HGF, KP-100IT, for the treatment of ALS were published in Journal of Clinical Pharmacology (11 DEC 2018, DOI: 10.1002/jcph.1355). It was indicated that intrathecal administration of KP-100IT was safe and tolerable. Following the Phase I study, an investigator-initiated Phase II study is currently underway to confirm therapeutic efficacy of KP-100IT against ALS.
New board members were selected at the 17th general shareholders meeting, and the board members appointed Kiichi Adachi as President and CEO.
Kringle Pharma successfully raised 200 million JPY in funding from THVP-1 Fund (General Partner: Tohoku University Venture Partners Co., Ltd.).
Kringle’s recombinant human HGF is now available as a research reagent at REPROCELL, Inc. For more information, please contact REPROCELL, Inc. through their website as follows. https://www.reprocell.com/
Kringle Pharma announces that the last subject has completed the follow-up period after dosing in the Phase I/II study of recombinant human HGF for acute spinal cord injury.