President/CEO Kunio Iwatani

Graduate of Faculty of Pharmacy, Osaka University Vice President of Takeda France S.A. Executive Vice President of TAP Pharmaceuticals, Inc. Director of International Product Management Dept. of Takeda Pharmaceutical Co., Ltd. President/CEO of Hokuriku Seiyaku Co.,Ltd Member of the Board, Abbott Japan Co., Ltd. President/CEO of Kringle Pharma, Inc.(present position) Outside Board Member, AnGes MG, Inc.(present position)

Exective Vice President Director, BD Kiichi Adachi, Ph.D.

Graduate of Doctoral Course of Graduate School of Agriculture and Life Science, Tokyo University Postdoctoral Research Associate, Purdue University, IN, U.S.A Research Scientist, Paradigm Genetics, Inc., NC, USA Chief Scientist at Biotechnology Center, Mitsui Global Strategic Studies Institute R&D Department Director, Kringle Pharma, Inc. Member of the Board, Kringle Pharma, Inc.(present position) Exective Vice Pesident of Kringle Pharma, Inc.(present position) Business Development Director, Kringle Pharma, Inc.(present position)

Director, R&D Keigo Hanada, D.V.M., Ph.D.

Graduate of Graduate School of Agriculture, Veterinary Medicine, Kagoshima University Government of Kagoshima Prefecture Graduate of Graduate School of Medicine, Kyoto University (Ph.D.) Chief Scientist, Kaken Pharmaceutical Co., Ltd. Senior Scientist, Tanabe Seiyaku Co., Ltd. R&D Department Director, Kringle Pharma, Inc.(present position) Invited Assistant Professor, Kringle Pharma Joint Research Division for Regenerative Drug Discovery, the Center for Advanced Science and Innovation at Osaka University Member of the Board, Kringle Pharma, Inc.(present position)

CSO Kunio Matsumoto, Ph.D.

Graduate of Graduate School of Science, Osaka University Doctor of Science (Ph.D.) Assistant Professor, Department of Dermatology, Osaka University Medical School Assistant Professor, Department of Biology, Faculty of Science, Kyushu University Associate Professor, Biomedical Research Center, Osaka University Associate Professor, Osaka University Graduate School of Medicine Member of the Board, Kringle Pharma, Inc.(present position) Professor, Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University (present position)

Auditor Haruhiko Mitsui

Graduate of School of Pharmaceutical Sciences, University of Shizuoka (Shizuoka Prefectural College of Pharmacy) General Manager, Sapporo Branch, Bayer Yakuhin, Ltd. Adviser, Health Net Co., Ltd. Auditor, Kringle Pharma, Inc. (present position)

Auditor Teruo Takata

Graduate of School of Law, Osaka University Sumitomo Bank, Ltd. (present Sumitomo Mitsui Banking Corporation) Asahi & Co.(present KPMG AZSA&Co.) Auditor, Kringle Pharma, Inc.(present position)

Auditor Yasuhiro Otani

Graduate of Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University Ota Showa & Co. (present Shin Nihon & Co.) General Manager, Otani CPA Office Established (present position) president, KVI Co.,Ltd (present position) senior partner, KVI Tax corporation (present position) senior partner, Mirai Audit corporation (present position) Auditor, Kringle Pharma, Inc. (present position)

Toshikazu Nakamura Ph.D. (Professor)

Graduate of Graduate School of Science, Osaka University, Doctor of Science (Ph.D.) Studied at University of California, San Diego (UCSD) Associate Professor at Enzyme Research Institution, Faculty of Medicine, University of Tokushima Professor, Department of Biology, Faculty of Sciences, Kyushu University. Professor, Graduate School of Medicine, Osaka University (present position)

Tadao Yamamoto (Legal Counsel)

Lecturer on International Contracts, Japan Intellectual Property Association Legal Adviser to the British Consulate & the Swiss Consulate in Japan Osaka City Overseas Business Adviser General Manager, Yamamoto Naito Law Company(present position)

Tsuyoshi Fujita, Ph.D.

Graduate of Graduate School of Science, Osaka University, Doctor of Science (Ph.D.) Studied at the University of Minnesota Deputy Director/Planning & Examination Director, Pharmaceutical Laboratory of Takeda Pharmaceutical Co., Ltd. Osaka TLO Coordinator, Osaka Industrial Promotion Organization (present position)

Joerg Michel M.D.(Surgical Specialist), D.M.(Doctor of Medicine)

Graduate of Johann Wolfgang V.Goethe University, Frankfurt Director of Corporate Medical Marketing Dept., Hoechst AG Director of Medico-Marketing Europe, Takeda Europe R&D Center CEO of Life Science Vision AG, Frankfurt/M., Germany (present position)

Toshio Kurumagawa (Financial Adviser)

Graduate of Osaka University Nippon Life Insurance Company Director of Investment Dept., Nippon Venture Capital Co., Ltd. Member of the Board, NISSAY CAPITAL Co., Ltd. (present position)

Masatomi Horiuchi

Graduate of Faculty of Management, Osaka University of Economics Member of the Board, Active Futaba Co., Ltd. Executive Director, Health Net Co., Ltd. (present position) Member of the Board, Kringle Pharma, Inc.

Masayoshi Matsumura

Graduate of Kyoto Pharmaceutical University President/CEO, Ohta Pharmaceutical Co., Ltd. President/CEO, Teikoku Medix Co., Ltd. Vice President, Teikoku Seiyaku Co., Ltd. Member of the Board, Kringle Pharma, Inc. Chairman/CEO, Medrx Inc. (present position)